Try to do this at home Mild and infrequent cases of itchy muscles can be treated at home. Try the following: Massage with a gentle, fragrance-free lotion. Take a cool shower or bath to slow blood flow. meditateto calm your mind and disassociate from the itch sensation. Try the legs up on the wall yoga pose for recovery after running. Apply ice to numb the sensation. NSAIDs such as ibuprofen, aspirin, or naproxen may reduce muscle inflammation and therefore reduce itching You should go to ሀኪም ቤት if your itching comes with: rash, nausea and diarrhea.